78 free questions · NCLEX-style

Infection Control & Patient Safety NCLEX Practice Questions

Infection control and patient safety questions are foundational to NCLEX success and appear throughout all categories. These questions test isolation precaution selection, hand hygiene priority, fall prevention protocols, medication administration safety, restraint guidelines, and the National Patient Safety Goals (NPSG) that directly drive clinical practice.

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What's covered in Infection Control & Patient Safety

  • Standard precautions (applies to ALL patients)
  • Transmission-based precautions (contact, droplet, airborne)
  • Hand hygiene — when to use soap and water vs hand sanitizer
  • Fall risk assessment and prevention interventions
  • Rights of medication administration (right patient, drug, dose, route, time)
  • Restraint use, monitoring, and documentation
  • National Patient Safety Goals (NPSG)
  • Surgical and procedural asepsis

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Question 1 of 78
Isolation precautionsEasy

Which client requires airborne precautions?

Common Infection Control & Safety NCLEX questions

Airborne (negative pressure room, N95 mask): TB, measles, varicella, disseminated herpes zoster. Droplet (surgical mask, private room or 3 feet distance): influenza, bacterial meningitis, mumps, pertussis, rubella, strep pharyngitis. Contact (gloves and gown): MRSA, VRE, C. difficile, wound infections, scabies. Standard precautions apply to every patient for every encounter.

Use soap and water (not alcohol-based hand sanitizer) when hands are visibly soiled or contaminated, after contact with Clostridioides difficile (C. diff) — alcohol does NOT kill C. diff spores, before eating, and after restroom use. Alcohol-based hand rub is effective and preferred for most clinical situations when hands are not visibly soiled.

Restraints are a last resort after all alternatives have failed. Require a provider order (renewed every 24 hours for medical-surgical, every 4 hours for behavioral health in adults). Assess circulation, sensation, and movement (CSM) of restrained extremities every 1-2 hours. Release restraints every 2 hours for ROM, toileting, hydration, and nutrition. Document ongoing assessment and the continued need for restraints. Restraints tied with quick-release knots to the bed frame (not side rails).

Assess fall risk on admission and with any change in condition using a validated tool (e.g., Morse Fall Scale). Interventions: bed in lowest position with brakes locked, call light within reach, non-skid footwear, adequate lighting, toileting assistance on schedule, minimize clutter, and educate the patient to call for help before ambulating. High-risk patients: consider bed alarms, 1:1 sitter, and medication review (sedatives, opioids, diuretics, and antihypertensives increase fall risk).

Key principles: a sterile field is contaminated if touched by any unsterile object, if it becomes wet (moisture wicks bacteria), or if it falls below waist level. Never turn your back on a sterile field. Open sterile packages away from you first. Sterile gloves: inside of the wrapper is sterile, glove dominant hand first. Surgical hand scrub: 3-5 minutes, keep hands above elbows. If there is ANY doubt about sterility, consider it contaminated and start over.

Key NPSG areas: use at least two patient identifiers before any procedure or medication (name and DOB — not room number), improve communication (read-back of verbal and telephone orders), label all medications on and off the sterile field, reduce patient harm from falls, prevent healthcare-associated infections (hand hygiene compliance, CAUTI/CLABSI bundles), and identify patient safety risks including suicide risk screening in behavioral health settings.

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